INNATE IMMUNE CELLSIN IMMUNE TOLERANCE AFTER LIVER TRANSPLANTATION

Currently, liver transplantation is the most effective treatment for end-stage disease. Immuno-suppressive agents are required to be taken after operations, which have significantly reduced rejection rates and improved short-term (<1 year) survival rates. However, post-transplant complications related immuno-suppressive therapy led development of new protocols aimed at protecting renal function preventing de novo cancer dysmetabolic syndrome. Donor specific immune tolerance, means mature systems recipients will not attack grafts under conditions without any immunosuppression therapies, considered optimal state transplantation. There been studies that shown some patients can reach this tolerance The intrahepatic system quite different from in other solid organs, especially innate system. It contains a variety cells, such as liver-derived dendritic Kupffer sinusoidal endothelial natural killer (NK) T (NKT) so on. Depending on their structures functions, these cells play important roles tolerance. In article, order deeper understanding tolerogenic functions liver, we summarized molecular mechanisms induced by